Integrated analysis of ribosomal DNA copy number and methylation using nanopore long-read sequencing
Zaka Wing-Sze Yuen, Noemie Leeder, Thejaani P. Udumanne, Andrew Garvie, Lee H. Wong, Emiliana Weiss, Lex M. van Loon, Austen R. D. Ganley, Ross D. Hannan, Eduardo Eyras, Nadine Hein
RICO quantifies rDNA copy number and methylation using nanopore sequencing, showing accurate results in simulations and human samples, with biological validation in mouse models.
bioRxiv · Jul 6, 2026 · PreprintBioinformatics