Lee H. Wong

RICO enables integrated analysis of ribosomal DNA copy number and methylation from nanopore long-read sequencing

RICO quantifies rDNA copy number and methylation using nanopore sequencing, showing accurate results in simulations and human/mouse samples, and revealing correlations between rDNA CN and methylation.

Y chromosome damage underlies testicular abnormalities in ATR-X syndrome

This study shows that ATRX mutations in Sertoli cells cause Y chromosome damage, leading to testicular abnormalities and cell death in ATR-X syndrome.

A conditional histone H3.3 mutation in mice orthologous to a driver of paediatric diffuse instrinsic pontine glioma

This paper introduces a conditional H3.3K27M mutation in mice to model paediatric diffuse intrinsic pontine glioma, showing dwarfism with intact growth hormone signaling.

A saturating mutagenesis CRISPR-Cas9 mediated functional genomic screen identifies cis- and trans-regulatory elements of Oct4 in embryonic stem cells

The paper identifies cis- and trans-regulatory elements of Oct4 in mESCs using ctSCAN-SMS, showing CREs are more active and conserved than TREs.

Histone demethylome map reveals combinatorial gene regulatory functions in embryonic stem cells

The paper identifies combinatorial functions of histone demethylases in gene regulation of mouse embryonic stem cells by analyzing their genome-wide binding patterns.