Austen R. D. Ganley

RICO quantifies rDNA copy number and methylation using nanopore sequencing, showing accurate results in simulations and human/mouse samples, and revealing correlations between rDNA CN and methylation.

The paper proposes a mechanism for villus elongation coupling tissue dewetting to cell differentiation, showing it can explain the formation of finger-like projections in developing tissues.

The paper identifies cell-type-specific transcription factors that bind rDNA and regulate rRNA transcription, showing CEBPA's role in promoting Pol I occupancy and rRNA synthesis in myeloid progenitors.

The paper introduces a method to estimate rDNA copy number using modal coverage and applies it to yeast isolates, finding population-level variation in copy numbers.

The paper examines the contrasting evolutionary patterns between coding and flanking regions of KRTAP1 genes across mammals, showing concerted evolution in coding regions and radiating evolution in flanking regions.

The paper identifies conserved regions in the human rDNA intergenic spacer using phylogenetic footprinting and integrates them with functional genomics data to suggest their potential roles in transcription and chromatin regulation.

The paper investigates how repeat elements shape 3D genome structure and transcription in the fungus Epichloë festucae, revealing a unique patchwork genome with repeat-rich blocks that regulate gene expression in symbiosis.