Zaka Wing-Sze Yuen

Integrated analysis of ribosomal DNA copy number and methylation using nanopore long-read sequencing

RICO quantifies rDNA copy number and methylation using nanopore sequencing, showing accurate results in simulations and human samples, with biological validation in mouse models.

The novel RNA polymerase I transcription inhibitor PMR-116 exploits a critical therapeutic vulnerability in a broad-spectrum of high MYC malignancies.

This study shows PMR-116, a second-generation RiBi inhibitor, effectively targets high-MYC cancers without causing DNA damage, suggesting RiBi as a viable cancer therapy.

Profiling age and body fluid DNA methylation markers using nanopore adaptive sampling

This study uses nanopore adaptive sampling to profile age and body fluid DNA methylation markers, identifying new age-correlated sites and validating known markers.

Prediction of m6A and m5C at single-molecule resolution reveals a cooccurrence of RNA modifications across the transcriptome

CHEUI predicts m6A and m5C modifications at single-molecule resolution, revealing co-occurrence of these modifications in mRNAs across cell lines and tissues.

Systematic benchmarking of tools for CpG methylation detection from Nanopore sequencing

The paper benchmarks CpG methylation detection tools from Nanopore sequencing, finding tradeoffs in accuracy and introducing a consensus method, METEORE, to improve results.