A TALS-like associated RTTN mutation impedes neural rosette formation in human cortical organoids
Justine Guguin, Ting-Yu Chen, Alicia Besson, Silvestre Cuinat, Eloïse Bertiaux, Lucile Boutaud, Nolan Ardito, Miren Imaz Murguiondo, Sara Cabet, Virginie Hamel, Sophie Thomas, Bertrand Pain, Patrick Edery, Audrey Putoux, Tang K. Tang, , Marion Delous
This study identifies an RTTN mutation that impairs neural rosette formation in human cortical organoids, linking it to microcephaly-like defects.
PLoS Genetics · Dec 16, 2024Peer-reviewedGenetic & Genomic Medicine