This study identifies EXOC6A's role in ciliogenesis by showing its interaction with Myo-Va and its involvement in vesicle dynamics and membrane remodeling during ciliogenesis.

bioRxiv · Jul 25, 2025Cell Biology

SSNA1 organizes the distal luminal centriolar network and promotes ciliogenesis without microtubule association

Yi-Chi Huang, Xiao-Jing Chong, Ting-Jui Ben Chang, Emma J. van Grinsven, Wei‐Ju Chen, Wen-Bin Hsu, Jeffrey Matthijn Beekman, Tang K. Tang, Anna S. Akhmanova, T. Tony Yang, Jen‐Hsuan Wei

This study identifies SSNA1 as a centriolar protein in the distal lumen that promotes ciliogenesis without microtubule association, challenging previous views of its function.

bioRxiv · Apr 28, 2025 · PreprintCell Biology

A TALS-like associated RTTN mutation impedes neural rosette formation in human cortical organoids

Justine Guguin, Ting-Yu Chen, Alicia Besson, Silvestre Cuinat, Eloïse Bertiaux, Lucile Boutaud, Nolan Ardito, Miren Imaz Murguiondo, Sara Cabet, Virginie Hamel, Sophie Thomas, Bertrand Pain, Patrick Edery, Audrey Putoux, Tang K. Tang, , Marion Delous

This study identifies an RTTN mutation that impairs neural rosette formation in human cortical organoids, linking it to microcephaly-like defects.

PLoS Genetics · Dec 16, 2024Peer-reviewedGenetic & Genomic Medicine

Centrosome Migration and Apical Membrane Formation in Polarized Epithelial Cells: Insights from the MDCK Cyst Model

Po‐Kai Wang, Keng-hui Lin, Tang K. Tang

The paper investigates the relationship between centrosome positioning, apical membrane formation, and polarity regulators in epithelial cells using MDCK cyst models, finding that centrosome-based polarity is not universal.

eLife · Oct 10, 2024Peer-reviewedCell Biology