This study compares the role of RPGRIP1L in human and mouse neural progenitor fate specification, finding distinct effects on motoneuron identity and SHH signaling.

Nature Communications · Apr 5, 2025Peer-reviewedDevelopmental Biology

A TALS-like associated RTTN mutation impedes neural rosette formation in human cortical organoids

Justine Guguin, Ting-Yu Chen, Alicia Besson, Silvestre Cuinat, Eloïse Bertiaux, Lucile Boutaud, Nolan Ardito, Miren Imaz Murguiondo, Sara Cabet, Virginie Hamel, Sophie Thomas, Bertrand Pain, Patrick Edery, Audrey Putoux, Tang K. Tang, , Marion Delous

This study identifies an RTTN mutation that impairs neural rosette formation in human cortical organoids, linking it to microcephaly-like defects.

PLoS Genetics · Dec 16, 2024Peer-reviewedGenetic & Genomic Medicine

TALPID3/KIAA0586 regulates multiple aspects of neuromuscular patterning during gastrointestinal development in animal models and human

Jean Marie Delalande, Nándor Nagy, Conor J. McCann, Dipa Natarajan, Julie E. Cooper, Gabriela Carreno, Dávid Dóra, Alison Campbell, Nicole Laurent, Polychronis Kemos, Sophie Thomas, Caroline Alby, Tania Attié‐Bitach, Stanislas Lyonnet, Malcolm P. O. Logan, , Alan J. Burns

This study investigates the role of TALPID3/KIAA0586 in gastrointestinal development across species, showing its impact on tissue patterning and neural crest cell behavior.

Frontiers in Molecular Neuroscience · Dec 23, 2021Peer-reviewedDevelopmental Biology