Context-dependent peptide recognition shapes tyrosine kinase substrate specificity beyond consensus motifs
Hannah Edstrom, Annette Thompson, Nolan O'Connor, Michael R. Shirts, Joel M. Kralj, Jerome M. Fox
The paper investigates how local sequence context influences PTK substrate specificity beyond consensus motifs, identifying sequence variations that affect kinase selectivity and compatibility.
bioRxiv · Jun 6, 2026 · PreprintBiochemistry