Michael R. Shirts

The paper investigates how local sequence context influences PTK substrate specificity beyond consensus motifs, identifying sequence variations that affect kinase selectivity and compatibility.

The paper identifies a hidden binding pocket in FabB that allows alternative acyl chain binding, contrasting with FabF's loss of long-chain binding upon mutation.

The paper designs dynamic biosensors for detecting nitazenes and their metabolites using computational methods, achieving low nanomolar detection limits and limited cross-reactivity.

The paper shows that nonspecific interactions in coiled-coil proteins can lead to liquid-liquid phase separation, and that linker segments can enhance this process without altering interaction specificity.

This study analyzes two engineered biosensors based on PYR1 to recognize different ligands, revealing binding mechanisms and computational methods for biosensor design.