Joel M. Kralj

The paper investigates how local sequence context influences PTK substrate specificity beyond consensus motifs, identifying sequence variations that affect kinase selectivity and compatibility.

The paper introduces cal-Seq, a pooled knockdown screen using CaMPARI to identify calcium handling genes, finding GPR99 as a regulator of histamine-induced calcium signaling.

The paper introduces an all-optical electrophysiology method called Optopatch to functionally characterize human iPSC-derived motor neurons in ALS models, finding altered electrophysiological properties in SOD1 A4V mutants.