Compact type II-C Cas9 nucleases with expanded PAM access and high fidelity for therapeutic genome editing
Qiaochu Wang, Gundra Sivakrishna Rao, Rashid Abdi Aman, Ahmed Saleh, Ahmed M. Kazlak, Maazallah Masood, Norhan Hassan, Magdy M. Mahfouz
The paper identifies and characterizes three compact type II-C Cas9 orthologs with improved PAM compatibility and high fidelity for genome editing in human cells.
bioRxiv · Aug 20, 2026 · PreprintBioengineering