Magdy M. Mahfouz

The paper profiles the metabolome and genomes of five amaranth cultivars to assess nutritional quality and genetic differences.

The paper identifies and characterizes compact Cas9d orthologs with high genome editing efficiency and specificity, suitable for AAV-based therapeutic applications.

The paper identifies and characterizes three compact type II-C Cas9 orthologs with improved PAM compatibility and high fidelity for genome editing in human cells.

This paper introduces PrimeStack, a method for site-specific integration of large DNA sequences into plant genomes, achieving high efficiency and phenotypic neutrality in rice.

This study identifies a molecular crosstalk between HAK5 and NPF6.2 transporters in Arabidopsis, showing their physical interaction and reciprocal inhibition affecting mineral nutrition.

This study identifies and engineers novel Cas12j orthologues into efficient genome editors with enhanced editing activity and specific sequence requirements.

This paper engineers Escherichia coli Nissle to deliver therapeutic peptides using CRISPR-Cas12 and an AI-based pipeline for peptide prediction.

The paper develops a new programmable site-specific nuclease system, PC-FIRA, that enables precise double-strand DNA breaks with high specificity and efficiency.

The paper develops a T7 RNAP-based DNA base editor to induce localized sequence diversification in plants, enabling synthetic evolution of herbicide-resistant ALS variants through selection pressure.

This study uses CRISPR/Cas13a to interfere with an RNA virus in plants, showing effective targeting of viral RNA sequences.