Multifaceted and evolutionarily dynamic interactions between Caenorhabditis elegans SPO-11 and its cofactors ensure proper formation of meiotic DNA double-strand breaks
Keita Kameda, Li Zhou, Nowa Matsubayashi, Carlos Mario Rodriguez-Reza, Meng Lin, Xuan Li, Tomoki Yoshioka, Aya Sato, Peter Mark Carlton
This paper investigates how SPO-11 and its cofactors, particularly DSB-1, regulate meiotic DNA double-strand break formation in C. elegans through dimerization and evolutionary adaptation.
bioRxiv · Aug 2, 2026 · PreprintCell Biology