Li Zhou

Multifaceted and evolutionarily dynamic interactions between Caenorhabditis elegans SPO-11 and its cofactors ensure proper formation of meiotic DNA double-strand breaks

This paper investigates how SPO-11 and its cofactors, particularly DSB-1, regulate meiotic DNA double-strand break formation in C. elegans through dimerization and evolutionary adaptation.

Large-scale integration of omics and electronic health records to identify potential risk protein biomarkers and therapeutic drugs for cancer prevention

This study integrates large-scale omics and electronic health records to identify risk proteins and drugs for cancer prevention, finding 101 novel proteins and three drugs associated with reduced colorectal cancer risk.

Targeting USP2 induces degradation of PML-RARα with or without drug-resistant mutations in acute promyelocytic leukemia

This study shows that inhibiting USP2 reduces PML-RAR protein levels in APL cells, including those with drug-resistant mutations, and induces apoptosis.

Engineering a Cell-Based Orthogonal Ubiquitin Transfer Cascade for Profiling the Substrates of RBR E3 Parkin

This study develops an orthogonal ubiquitin transfer cascade to profile Parkin substrates, revealing roles in DNA replication, protein transport, and mitophagy.

Unraveling the Molecular Mechanisms of ABHD5 Membrane Targeting

This study identifies a dual-site membrane recognition mechanism in ABHD5 that enables its activation and regulation of lipid metabolism.

CircSMAD3 represses VSMC phenotype switching and neointima formation via promoting hnRNPA1 ubiquitination degradation

This study identifies circSMAD3 as a regulator that suppresses vascular smooth muscle cell proliferation and neointima formation by promoting hnRNPA1 degradation.

Presynaptic NMDA receptors cooperate with local action potentials to implement activity-dependent GABA release from the reciprocal olfactory bulb granule cell spine

The paper investigates how presynaptic NMDA receptors work with local action potentials to enable activity-dependent GABA release from olfactory bulb granule cells.

Inward tubulation of the plasma membrane expedites membrane exchange and receptor presentation

The paper identifies inward tubulation of the plasma membrane as a mechanism to enhance membrane exchange and receptor presentation.