E2F1 methylation by SETD6 regulates SETD6 expression via positive feedback mechanism
Margarita Kublanovsky, Gizem T. Ulu, Sara Weirich, Nurit Levy, Michal Feldman, Albert Jeltsch, Dan Levy
The paper identifies a positive feedback loop where SETD6 methylates E2F1 at K117, enhancing SETD6 expression, and shows that this methylation is critical for maintaining SETD6 levels.
bioRxiv · Jun 27, 2023 · PreprintMolecular Biology