Enhancer-targeting CRISPR screens at coronary artery disease loci suggest shared mechanisms of disease risk
Markus O Ramste, Chad S. Weldy, Soumya Kundu, Quanyi Zhao, Daniel Yuhang Li, Kayla Brand, Disha Sharma, Amanda Ramste, Evelyn Jagoda, Judhajeet Ray, Roxanne Diaz Caceres, James Galante, Andreas R. Gschwind, Nuutti Lahtinen, Trieu Nguyen, , Thomas Quertermous
The paper identifies causal genetic mechanisms at CAD GWAS loci using CRISPR screens and chromatin analysis, revealing enhancer-gene links and ancestry/sex-specific risk factors.
medRxiv · Aug 28, 2025 · PreprintGenetic & Genomic Medicine