Markus O Ramste

An in vitro System for Studying Osteochondrogenic Differentiation of Smooth Muscle Cells and Modeling Intimal Vascular Calcification

This paper develops an in vitro system that mimics osteochondrogenic differentiation of smooth muscle cells and intimal vascular calcification, showing distinct transcriptional states compared to standard calcification assays.

Vascular smooth muscle cell atherosclerosis trajectories characterized at single cell resolution identify causal transcriptomic and epigenomic mechanisms of disease risk

The paper characterizes atherosclerosis trajectories in vascular smooth muscle cells using single-cell data and identifies causal transcriptomic and epigenomic mechanisms of CAD risk.

Smooth muscle expression of RNA editing enzyme ADAR1 controls activation of RNA sensor MDA5 in atherosclerosis

The paper links ADAR1-mediated RNA editing in smooth muscle cells to regulation of MDA5 activation, showing its role in atherosclerosis progression and vascular calcification.

Enhancer-targeting CRISPR screens at coronary artery disease loci suggest shared mechanisms of disease risk

The paper identifies causal genetic mechanisms at CAD GWAS loci using CRISPR screens and chromatin analysis, revealing enhancer-gene links and ancestry/sex-specific risk factors.

Single cell variant to enhancer to gene map for coronary artery disease

This paper links CAD GWAS variants to causal genes in SMCs using single-cell chromatin accessibility and Hi-C data, creating a scV2E2G map for disease mechanism discovery.

Aryl-hydrocarbon receptor in smooth muscle cells protect against dioxin induced adverse remodeling of atherosclerosis

This study shows dioxin exposure accelerates atherosclerosis by promoting inflammatory smooth muscle cell phenotypes and oxidative stress, with AHR in SMC providing protective effects.

The alpha-2A-adrenergic receptor (ADRA2A) modulates susceptibility to Raynaud's syndrome

This study identifies ADRA2A as a major risk locus for Raynaud's syndrome through genome-wide association analysis and functional validation in vascular smooth muscle cells.