Disha Sharma

A cell and transcriptome atlas of human arterial vasculature

This study creates a transcriptomic and spatial atlas of human arterial segments, revealing cell-type and segment-specific heterogeneity linked to vascular disease risk.

Smooth muscle expression of RNA editing enzyme ADAR1 controls activation of RNA sensor MDA5 in atherosclerosis

The paper links ADAR1-mediated RNA editing in smooth muscle cells to regulation of MDA5 activation, showing its role in atherosclerosis progression and vascular calcification.

Enhancer-targeting CRISPR screens at coronary artery disease loci suggest shared mechanisms of disease risk

The paper identifies causal genetic mechanisms at CAD GWAS loci using CRISPR screens and chromatin analysis, revealing enhancer-gene links and ancestry/sex-specific risk factors.

Plasma proteomic signatures for type 2 diabetes mellitus and related traits in the UK Biobank cohort

This study identifies plasma proteomic signatures that modestly improve prediction of incident type 2 diabetes compared to clinical and genetic factors.

A plasma proteomic signature for atherosclerotic cardiovascular disease risk prediction in the UK Biobank cohort

This paper develops a plasma proteomic signature for predicting atherosclerotic cardiovascular disease risk using UK Biobank data and finds it modestly improves prediction over clinical and genetic factors.

A functional genomic framework to elucidate novel causal non-alcoholic fatty liver disease genes

This study identifies novel causal genes for NAFLD using a combination of GWAS, genetic colocalization, and CRISPRi functional screens.

Molecular mechanisms of coronary artery disease risk at the PDGFD locus

This study identifies PDGFD as a CAD risk gene, showing it promotes SMC expansion, migration, and inflammation, contributing to vascular calcification and plaque recruitment.

Comprehensive assessment of Indian variations in the druggable kinome landscape highlights distinct insights at the sequence, structure and pharmacogenomic stratum

This study analyzes Indian genetic variations in the kinome to identify sequence, structural, and pharmacogenomic differences compared to global datasets, highlighting implications for drug safety and adverse reactions.

CROP-Seq: a single-cell CRISPRi platform for characterizing candidate genes relevant to metabolic disorders in human adipocytes

CROP-Seq uses CRISPRi and scRNA-Seq to screen gene targets in adipocytes, identifying gene knock-down effects and novel regulators of adipogenesis and metabolic disease.

The epigenomic landscape of single vascular cells reflects developmental origin and identifies disease risk loci

The paper identifies vascular site-specific epigenomic and transcriptomic features and links them to disease risk loci using single-cell data and GWAS integration.

Initial insights into the genetic epidemiology of SARS-CoV-2 isolates from Kerala suggest local spread from limited introductions

The paper analyzes SARS-CoV-2 isolates from Kerala, India, identifying 166 unique variants, including 4 novel ones, and reports on their genetic epidemiology and potential impact on diagnostics.

High throughput detection and genetic epidemiology of SARS-CoV-2 using COVIDSeq next generation sequencing

This study evaluates the COVIDSeq protocol for SARS-CoV-2 detection and genetic epidemiology, showing high concordance with RT-PCR and identifying novel variants and lineages.

Insights from Genomes and Genetic Epidemiology of SARS-CoV-2 isolates from the state of Andhra Pradesh

This study sequenced SARS-CoV-2 genomes from Andhra Pradesh, identifying 564 variants including 15 novel ones and 4 associated with increased infectivity.

A genome-wide circular RNA transcriptome in Rat

The paper identifies and characterizes circular RNAs in rat using multiple computational pipelines and validates some candidates through experimental methods.