Liquid-liquid phase separation and aggregation of the prion protein globular domain modulated by a high-affinity DNA aptamer
C. O. Matos, Y. M. Passos, M. J. Amaral, B. Macedo, M. Tempone, O. C. L. Bezerra, M. O. Moraes, M. S. Almeida, G. Weber, S. Missailidis, J. L. Silva, A. S. Pinheiro, Y. Cordeiro
This study identifies DNA aptamers that modulate liquid-liquid phase separation of prion protein, revealing structural effects on aggregation and potential implications for TSEs.
bioRxiv · Jun 3, 2019Biophysics