G. Weber

YAP1 is a key regulator of EWS::FLI1-dependent malignant transformation upon IGF-1 mediated reprogramming of bone mesenchymal stem cells

The paper shows that IGF-1 reprograms bone mesenchymal stem cells in EWS::FLI1-mutant mice, leading to tumor formation, with Yap1 playing a central role, and suggests combined IGF-1R and YAP/TEAD inhibition as a potential treatment.

Growth and tension in explosive fruit

The paper investigates how tension in exploding seed pods of Cardamine hirsuta is generated through active cell growth and microtubule-controlled cellulose microfibril orientation.

dATP Elevation Induces Myocardial Metabolic Remodeling to Support Improved Cardiac Function

This study shows that elevating dATP in cardiomyocytes improves cardiac function by enhancing contractility and metabolic flexibility through mitochondrial remodeling.

Anatomical Structures, Cell Types, and Biomarkers Tables Plus 3D Reference Organs in Support of a Human Reference Atlas

The paper reviews efforts to create human anatomical structures, cell types, and biomarkers tables and 3D reference organs to support a Human Reference Atlas, with use cases showing their utility in biomedical research.

Liquid-liquid phase separation and aggregation of the prion protein globular domain modulated by a high-affinity DNA aptamer

This study identifies DNA aptamers that modulate liquid-liquid phase separation of prion protein, revealing structural effects on aggregation and potential implications for TSEs.

A novel photoactivatable tool for intermediate filament disruption indicates a role for keratin filaments in early embryogenesis

This paper introduces a photoactivatable tool to disrupt keratin intermediate filaments and shows its role in morphogenetic movements during Xenopus embryogenesis.