Targeted Sequencing Workflows for Comprehensive Drug Resistance Profiling of Mycobacterium tuberculosis cultures using Illumina MiSeq and Nanopore MinION: Comparison of analytical and diagnostic performance, turnaround time and cost
K. Tafess, T. T. L. Ng, H. Y. Lao, K. S.-S. Leung, K. K.-G. Tam, R. Rajwani, S. T. Y. Tam, L. P. K. Ho, C. M. K. Chu, D. Gonzalez, C. Sayada, O. C.-K. Ma, B. H. Nega, G. Ameni, W.-C. Yam, G. K. H. Siu
This paper compares two sequencing workflows for drug resistance profiling of M. tuberculosis using Illumina MiSeq and Nanopore MinION, finding comparable accuracy with differences in speed and cost.
bioRxiv · Sep 8, 2019Microbiology