Construction of lux-based promoter-reporter platforms in Mycobacterium bovis BCG for screening of drug repurposing small-molecule compounds as new anti-tuberculosis drugs
L. Zhu, A. W.-t. Lee, K. K.-L. WU, P. GAO, K. K.-G. Tam, R. Rajwani, G. C. CHABURTE, T. T.-L. NG, C. T. M. Chan, H.-Y. Lao, W.-C. Yam, R. Y.-T. Kao, G. K. H. Siu
This study constructs a lux-based promoter-reporter system to screen small-molecule compounds for anti-TB activity, identifying one antibiotic and two anti-virulence agents.
bioRxiv · Nov 5, 2021 · PreprintMicrobiology