E. Lundberg

High-Resolution In Silico Painting with Generative Models

This paper introduces a simplified VQGAN training scheme for generating multi-channel organelle staining from bright field images, achieving top performance in a benchmark challenge.

Biotic and abiotic drivers of ecosystem functioning differ between a temperate and a tropical region

This study compares biotic and abiotic drivers of ecosystem functioning in temperate and tropical regions, finding differing patterns and drivers between the two zones.

coRIC map: a framework for the exploration of multifaceted subcellular RNA-binding proteins

The paper introduces coRIC map, an experimental and analytical framework to study subcellular RNA-binding protein dynamics and interactions, revealing new functions and stress responses.

ISG15-modification of the Arp2/3 complex restricts pathogen spread

This study shows ISG15 modifies the Arp2/3 complex to restrict pathogen spread by slowing actin filament formation and stabilizing structures, but pathogens like Listeria exploit dysregulated ISGylation to enhance spread.

Uncovering molecular grammars of intrinsically disordered regions that organize nucleolar fibrillar centers

The paper identifies molecular grammars in intrinsically disordered regions of nucleolar proteins that drive phase separation to form nucleolar substructures.

Spatiotemporal dynamics of DNA repair proteins between the Golgi and nucleus maintain genomic stability.

The paper identifies dynamic redistribution of DNA repair proteins between the Golgi and nucleus in response to DNA damage, revealing a spatiotemporal coordination role for the Golgi in maintaining genomic stability.

Subcellular mapping of the protein landscape of SARS-CoV-2 infected cells for target-centric drug repurposing

The paper uses immunofluorescence to analyze host protein changes in SARS-CoV-2 infection and identifies three drugs that reduce antiviral activity.

DeepImageJ: A user-friendly environment to run deep learning models in ImageJ

DeepImageJ provides a user-friendly environment for using pre-trained deep learning models in ImageJ for biomedical image analysis tasks.

Spatiotemporal dissection of the cell cycle with single-cell proteogenomics

The paper maps spatiotemporal proteomic heterogeneity during the cell cycle using single-cell proteogenomics and identifies 235 cell cycle-associated proteins.

Mapping the nucleolar proteome reveals a spatiotemporal organization related to intrinsic protein disorder

The paper maps the human nucleolar proteome, identifies a new subcompartment, and shows intrinsic disorder levels are higher in nucleolar and mitotic proteins.

A sample preparation protocol for high throughput immunofluorescence of suspension cells

This paper presents a protocol for high-throughput immunofluorescence of suspension cells, enabling systematic protein localization analysis in hematopoietic cells.