Optimised whole-genome CRISPR interference screens identify ARID1A-dependent growth regulators in human induced pluripotent stem cells
S. Usluer, P. Hallast, L. Crepaldi, Y. Zhou, K. Urgo, C. Dincer, J. Su, G. Noell, K. Alasoo, O. El Garwany, S. Gerety, B. Newman, O. M. Dovey, L. Parts
The paper optimizes CRISPR interference screens in human iPSCs using dCas9-KRAB-MeCP2, identifies ARID1A-dependent growth regulators, and finds proteasome-related genes as synthetic lethal targets.
bioRxiv · Oct 3, 2022 · PreprintCell Biology