EFF-1 promotes muscle fusion, paralysis and retargets infection by AFF-1-coated viruses in C. elegans
A. Meledin, X. Li, E. Matveev, B. Gildor, O. Katzir, B. Podbilewicz
The paper shows that EFF-1 induces muscle fusion in C. elegans, causing paralysis and morphological defects, and demonstrates that AFF-1-coated viruses can infect EFF-1-expressing muscles, revealing potential applications in gene therapy and viral-host interactions.
bioRxiv · May 17, 2020 · PreprintCell Biology