O. Kepp

A lymph node-to-tumour PD-L1+macrophage circuit antagonizes dendritic cell immunotherapy

This paper shows that DC vaccines can activate PD-L1+ macrophages in lymph nodes and tumors, creating an immunosuppressive circuit that limits their effectiveness, but this can be overcome by combining with PD-L1 blockade.

The Chlamydia protein CpoS modulates the inclusion microenvironment and restricts the interferon response by acting on Rab35