O. M. Rueda

Clustering of HR+/HER2- breast cancer in an Asian cohort is driven by immune phenotypes

This study identifies immune phenotype-driven clustering in HR+/HER2- breast cancer from an Asian cohort, deviating from the luminal A-luminal B classification seen in European populations.

Modelling drug responses and evolutionary dynamics using triple negative breast cancer patient-derived xenografts

This paper uses TNBC patient-derived xenografts to model drug responses and evolutionary dynamics, revealing a novel mechanism of olaparib response and synergistic effects with salinomycin.

Gene expression signature for predicting homologous recombination deficiency in triple-negative breast cancer

The paper develops a gene expression classifier to predict homologous recombination deficiency in triple-negative breast cancer using RNA-seq and WES data from a Malaysian cohort, achieving high accuracy in validation datasets.

Transcriptomically-inferred PI3K activity and stemness show a counterintuitive correlation with PIK3CA genotype in breast cancer

The paper finds a biphasic relationship between PIK3CA genotype and transcriptionally inferred PI3K activity and stemness in breast cancer, with mutant allele dosage affecting these traits differently.

Germline APOBEC3B deletion in Asian women increases somatic hypermutation in breast cancer that is associated with Her2 subtype, PIK3CA mutations, immune activation, and increased survival

The Molecular Landscape of Asian Breast Cancers Reveals Clinically Relevant Population-Specific Differences

This study analyzes molecular profiles of 560 Asian breast tumors, revealing population-specific differences in subtypes, mutations, and immune scores compared to Caucasian populations.