Author

R. R. Madsen

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

Click to filter author papers

Cancer Biology· 2 Cell Biology· 1

Signature Assays, Organisms & Methods

Click to filter · or open tag

Organism:human· 3 Assay:bulk RNA-seq· 1 Research Focus:cancer & tumor microenvironment· 1 Research Focus:cell signaling & trafficking· 1 Research Focus:differential expression· 1 Approach:experimental assay· 1 Research Focus:gene regulatory network inference· 1 Approach:genetic perturbation / CRISPR· 1

Frequent Co-Authors

B. Vanhaesebroeck· 2 shared A. Byron· 1 shared A. L. Hillis· 1 shared A. Toker· 1 shared A. Wirth· 1 shared B. Carroll· 1 shared C. Caldas· 1 shared D. A. Fruman· 1 shared

Activity by Year

2020-2024 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 17 mutual co-author links

Click any collaborator node to inspect or filter shared papers

Focal author (center)Selected co-authorORCID co-authorUnlinked name

Curved chords = mutual co-authorship

2 shared papersCell Biology

B. Vanhaesebroeck

Mutual co-authors in cluster

Author profile →

3 papers

Recent·Most cited

Cholesterol biosynthesis inhibition synergizes with AKT inhibitors in triple-negative breast cancer

A. Toker, A. L. Hillis, T. D. Martin, H. E. Manchester, J. M. Hogstrom, N. Zhang, E. Lecky, N. Kozlova, N. S. Persky, D. E. Root, M. Brown, K. Cichowski, S. J. Elledge, T. Muranen, D. A. Fruman, , R. R. Madsen

This study identifies a synergistic effect between AKT inhibitors and pitavastatin in killing triple-negative breast cancer cells by targeting cholesterol trafficking.

bioRxiv · Jan 16, 2024 · PreprintCancer Biology

mTORC1 activity is supported by spatial association with focal adhesions

Y. Rabanal-Ruiz, A. Byron, A. Wirth, R. R. Madsen, L. Sedlackova, G. Hewitt, G. Nelson, J. Stingele, R. Faessler, B. Vanhaesebroeck, O. Maddocks, E. Ponimaskin, B. Carroll, V. I. Korolchuk

This study shows that mTORC1 activation by growth factors and amino acids requires its spatial association with focal adhesions, independent of lysosomal distribution.

bioRxiv · Nov 20, 2020Cell Biology

Transcriptomically-inferred PI3K activity and stemness show a counterintuitive correlation with PIK3CA genotype in breast cancer

R. R. Madsen, O. M. Rueda, X. Robin, C. Caldas, R. K. Semple, B. Vanhaesebroeck

The paper finds a biphasic relationship between PIK3CA genotype and transcriptionally inferred PI3K activity and stemness in breast cancer, with mutant allele dosage affecting these traits differently.

bioRxiv · Jul 9, 2020 · PreprintCancer Biology