Author

A. Nagano

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Cancer Biology· 3

Signature Assays, Organisms & Methods

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Organism:human· 3 Assay:bulk RNA-seq· 2 Research Focus:cancer & tumor microenvironment· 2 Approach:experimental assay· 2 Research Focus:cell type annotation· 1 Research Focus:clustering· 1 Research Focus:drug response / drug discovery· 1 Assay:metabolomics· 1

Frequent Co-Authors

A. Bruna· 1 shared A. G. Martin· 1 shared A. Giovannetti· 1 shared A. Rowan· 1 shared A. Shea· 1 shared A. Suarez-Bonnet· 1 shared Argyr· 1 shared B. Almeida· 1 shared

Activity by Year

2019-2023 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 21 mutual co-author links

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1 shared paperCancer Biology

A. Bruna

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Author profile →

3 papers

Recent·Most cited

Modelling drug responses and evolutionary dynamics using triple negative breast cancer patient-derived xenografts

A. Shea, Y. Eyal-Lubling, D. Guerrero-Romero, R. Manzano Garcia, W. Greenwood, M. O'Reilly, D. Georgopoulou, M. Callari, G. Lerda, S. Wix, A. Giovannetti, R. Masina, E. Esmaeilishirazifard, A. G. Martin, A. Nagano, , A. Bruna

This paper uses TNBC patient-derived xenografts to model drug responses and evolutionary dynamics, revealing a novel mechanism of olaparib response and synergistic effects with salinomycin.

bioRxiv · Jan 10, 2023 · PreprintCancer Biology

Targeted cancer therapy induces APOBEC fuelling the evolution of drug resistance

D. R. Caswell, M. K. Mayekar, P. Gui, E. K. Law, N. I. Vokes, C. M. Ruiz, M. Dietzen, M. Angelova, C. Bailey, O. Pich, B. Bakker, W. Wu, T. J. Humpton, D. L. Kerr, W. Hill, , Argyr

This study shows that targeted cancer therapy induces APOBEC-mediated mutagenesis, promoting drug resistance by increasing genetic diversity through mechanisms involving NF-κB activation and reduced DNA repair.

bioRxiv · Dec 18, 2020Cancer Biology

The breast cancer oncogene IKKε coordinates mitochondrial function and serine metabolism

R. Xu, W. Jones, E. Wilcz-Villega, S. Costa, V. Rajeeve, R. B. Bentham, K. Bryson, A. Nagano, B. Yaman, S. Olendo Barasa, Y. Wang, C. Chelala, P. Cutillas, G. Szabadkai, C. Frezza, K. Bianchi

This study shows that IKKε, a breast cancer oncogene, reprograms mitochondrial function and serine metabolism independently of its canonical signaling role, promoting cancer cell proliferation.

bioRxiv · Nov 26, 2019Cancer Biology