Re-evaluation of lysyl hydroxylation in the collagen triple helix: lysyl hydroxylase 1 and prolyl 3-hydroxylase 3 have site-differential and collagen type-dependent roles in lysine hydroxylation.
Y. Ishikawa, Y. Taga, K. Zientek, N. Mizuno, A. M. Salo, O. Semenova, S. Tufa, D. R. Keene, P. Holden, K. Mizuno, J. Myllyharju, H. P. Bächinger
This study investigates the roles of P3H3 and LH1 in lysyl hydroxylation in collagen, finding distinct site-specific and collagen-type-dependent functions.
bioRxiv · Dec 16, 2019Biochemistry