Author

D. R. Keene

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Cell Biology· 2 Biochemistry· 1 Bioengineering· 1

Signature Assays, Organisms & Methods

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Approach:experimental assay· 4 Organism:mouse· 4 Research Focus:cell type annotation· 2 Research Focus:development & morphogenesis· 2 Research Focus:differential expression· 1 Assay:proteomics· 1

Frequent Co-Authors

S. F. Tufa· 3 shared A. Stabio· 2 shared B. A. Pryce· 2 shared G.-K. Tan· 2 shared R. Schweitzer· 2 shared A. A. Fernandes· 1 shared A. M. Salo· 1 shared B.-h. Koo· 1 shared

Activity by Year

2019-2022 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 21 mutual co-author links

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3 shared papersCell Biology

S. F. Tufa

Mutual co-authors in cluster

Author profile →

4 papers

Recent·Most cited

Characterization of TGFβ-induced tendon-like structure in scaffold-free three-dimensional tendon cell culture

B.-h. Koo, Y. Lee, N. R. Park, S.-J. Heo, D. M. Hudson, A. A. Fernandes, C. S. Friday, M. W. Hast, D. T. Corr, D. R. Keene, S. F. Tufa, N. A. Dyment, K. S. Joeng

This study develops a scaffold-free 3D tendon culture system to investigate TGFβ-induced tendon-like structure formation and its effects on cell behavior and matrix organization.

bioRxiv · Jun 8, 2022 · PreprintBioengineering

Cell autonomous TGF-beta signaling is essential for cell recruitment into degenerating tendons

G.-K. Tan, B. A. Pryce, A. Stabio, D. R. Keene, S. F. Tufa, R. Schweitzer

The paper identifies cell-autonomous TGF-beta signaling as essential for recruiting Sox9-expressing stem/progenitor cells into degenerating tendons.

bioRxiv · Nov 11, 2020 · PreprintCell Biology

Re-evaluation of lysyl hydroxylation in the collagen triple helix: lysyl hydroxylase 1 and prolyl 3-hydroxylase 3 have site-differential and collagen type-dependent roles in lysine hydroxylation.

Y. Ishikawa, Y. Taga, K. Zientek, N. Mizuno, A. M. Salo, O. Semenova, S. Tufa, D. R. Keene, P. Holden, K. Mizuno, J. Myllyharju, H. P. Bächinger

This study investigates the roles of P3H3 and LH1 in lysyl hydroxylation in collagen, finding distinct site-specific and collagen-type-dependent functions.

bioRxiv · Dec 16, 2019Biochemistry

TGF-β signaling is critical for maintenance of the tendon cell fate

G.-K. Tan, B. A. Pryce, A. Stabio, J. V. Brigande, C. Wang, Z. Xia, S. F. Tufa, D. R. Keene, R. Schweitzer

This study shows TGF-β signaling is essential for maintaining tendon cell identity, as its disruption leads to dedifferentiation and loss of markers in tenocytes.

bioRxiv · Oct 29, 2019 · PreprintCell Biology