K. Mizuno

Interaction between Solo and PDZ-RhoGEF is involved in actin cytoskeletal remodeling and response to substrate stiffness

This study identifies PDZ-RhoGEF as an interacting partner of Solo, showing their role in actin cytoskeletal remodeling and response to substrate stiffness.

MARK3-mediated Slingshot-1 phosphorylation is essential for polarized lamellipodium formation

This study shows that MARK3-mediated phosphorylation of SSH1 is necessary for its release from F-actin and translocation to lamellipodia, enabling polarized cell migration.

Copy number of the eukaryotic rRNA gene can be counted comprehensively

The paper introduces an improved method to comprehensively measure eukaryotic rRNA gene copy numbers, enabling better analysis of microbial eukaryote communities.

Massive RNA editing in ascetosporean mitochondria

The paper identifies massive A-to-I and C-to-U RNA editing in Paradinida ascetosporeans, showing their mitochondria are functionally active, unlike Mikrocytida, and reveals ADAR localization in mitochondria.

Functional hierarchy among different Rab27 effectors involved in secretory granule exocytosis

The paper investigates the functional hierarchy of Rab27 effectors in insulin secretion by comparing exocytic phenotypes in beta cells lacking different combinations of effectors.

Bi-phasic effect of gelatin in myogenesis and skeletal muscle regeneration

This study identifies a bi-phasic effect of gelatin on skeletal muscle regeneration through ROS-mediated signaling, showing low-dose gelatin promotes regeneration while high-dose inhibits it.

Developing High-Affinity Decoy Receptor Optimized for Multiple Myeloma and Diffuse Large B Cell Lymphoma Treatment

This paper develops an engineered sBCMA-Fc fusion protein with enhanced binding affinity to APRIL and BAFF, showing improved antitumor activity against multiple myeloma and diffuse large B cell lymphoma in preclinical models.

Double-observer approach with camera traps: Towards an unbiased density estimation of unmarked animal populations

The paper introduces a double-observer approach with camera traps to correct detection bias in unmarked animal populations and shows it can improve density estimation accuracy.

Novel multicellular prokaryote discovered next to an underground stream

The paper describes the discovery of a new bacterium with multicellular-like behavior, suggesting a potential missing link in the evolution of multicellularity.

Phosphorylation and dephosphorylation of Ser852 and Ser889 control clustering, localization, and function of PAR-3

This study shows that phosphorylation and dephosphorylation of PAR-3 at Ser852 and Ser889 regulate its clustering, localization, and function in cell polarity and junction formation.

Re-evaluation of lysyl hydroxylation in the collagen triple helix: lysyl hydroxylase 1 and prolyl 3-hydroxylase 3 have site-differential and collagen type-dependent roles in lysine hydroxylation.

This study investigates the roles of P3H3 and LH1 in lysyl hydroxylation in collagen, finding distinct site-specific and collagen-type-dependent functions.