Phase separation by the Sterile Alpha Motif of Polyhomeotic compartmentalizes Polycomb Group proteins and enhances their activity
E. Seif, J. J. Kang, C. Sasseville, O. Senkovitch, A. Kaltashov, E. L. Boulier, I. Kapur, C. A. Kim, N. Francis
The paper shows that the SAM domain of Polyhomeotic promotes phase separation, forming condensates that enhance PRC1 activity and chromatin compaction.
bioRxiv · Aug 20, 2020Biochemistry