Author

N. Francis

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Biochemistry· 2 Cell Biology· 1

Signature Assays, Organisms & Methods

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Research Focus:cell type annotation· 3 Research Focus:chromatin & epigenetic regulation· 2 Approach:experimental assay· 2 Research Focus:protein folding & dynamics· 2 Approach:statistical model· 2 Assay:ChIP-seq· 1 Approach:deep learning· 1 Research Focus:differential expression· 1

Frequent Co-Authors

J. J. Kang· 2 shared A. Kaltashov· 1 shared A. R. Green· 1 shared B. Gottgens· 1 shared C. A. Kim· 1 shared C. Basford· 1 shared C. Grey-Wilson· 1 shared C. S. Johnson· 1 shared

Activity by Year

2020-2022 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 17 mutual co-author links

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2 shared papersBiochemistry

J. J. Kang

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Author profile →

3 papers

Recent·Most cited

Adaptation to ex vivo culture drives human haematopoietic stem cell loss of repopulation capacity in a cell cycle independent manner

C. S. Johnson, K. Sham, S. Belluschi, X. Wang, W. Lau, K. B. Kaufmann, G. Krivdova, E. F. Calderbank, N. Mende, J. McLeod, G. Mantica, M. J. Williams, C. Grey-Wilson, M. Drakopoulos, S. Sinha, , E. Laurenti

This study shows that human LT-HSC loss of repopulation capacity during ex vivo culture occurs rapidly after adaptation, independent of cell cycle progression.

bioRxiv · Nov 17, 2022 · PreprintCell Biology

Phase separation by the Sterile Alpha Motif of Polyhomeotic compartmentalizes Polycomb Group proteins and enhances their activity

E. Seif, J. J. Kang, C. Sasseville, O. Senkovitch, A. Kaltashov, E. L. Boulier, I. Kapur, C. A. Kim, N. Francis

The paper shows that the SAM domain of Polyhomeotic promotes phase separation, forming condensates that enhance PRC1 activity and chromatin compaction.

bioRxiv · Aug 20, 2020Biochemistry

DNA binding reorganizes the intrinsically disordered C-terminal region of PSC in Drosophila PRC1

J. J. Kang, D. Faubert, J. Boulais, N. Francis

This study uses XL-MS and protein footprinting to show that DNA binding reorganizes the intrinsically disordered C-terminal region of PSC in Drosophila PRC1, bringing its DNA-binding site closer to the complex core.

bioRxiv · Jun 2, 2020Biochemistry