Author

E. Seif

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Biochemistry· 2

Signature Assays, Organisms & Methods

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Assay:ChIP-seq· 2 Research Focus:chromatin & epigenetic regulation· 2 Approach:experimental assay· 2 Research Focus:cell type annotation· 1 Organism:Drosophila· 1 Research Focus:protein folding & dynamics· 1

Frequent Co-Authors

A. Kaltashov· 1 shared C. A. Kim· 1 shared C. Sasseville· 1 shared E. L. Boulier· 1 shared I. Kapur· 1 shared J. J. Kang· 1 shared N. Francis· 1 shared N. J. Francis· 1 shared

Activity by Year

2020-2023 · peak 1/yr

Co-Author Collaboration Network

9 top collaborators · 28 mutual co-author links

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1 shared paperBiochemistry

A. Kaltashov

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2 papers

Recent·Most cited

A two-step mechanism for creating stable, condensed chromatin by the Polycomb complex PRC1

E. Seif, N. J. Francis

This study reveals a two-step mechanism by which the PRC1 complex creates stable chromatin condensates through phase separation and chromatin bridging.

bioRxiv · Dec 6, 2023 · PreprintBiochemistry

Phase separation by the Sterile Alpha Motif of Polyhomeotic compartmentalizes Polycomb Group proteins and enhances their activity

E. Seif, J. J. Kang, C. Sasseville, O. Senkovitch, A. Kaltashov, E. L. Boulier, I. Kapur, C. A. Kim, N. Francis

The paper shows that the SAM domain of Polyhomeotic promotes phase separation, forming condensates that enhance PRC1 activity and chromatin compaction.

bioRxiv · Aug 20, 2020Biochemistry