Defining Substrate Requirements for Cleavage of Farnesylated Prelamin A by the Integral Membrane Zinc Metalloprotease ZMPSTE24
K. M. Wood, E. D. Spear, O. W. Mossberg, K. O. Odinammadu, W. Xu, S. Michaelis
This study identifies flexible substrate requirements for ZMPSTE24 cleavage of prelamin A using a yeast system, showing that both the C-terminal and N-terminal regions have variable length and composition needs.
bioRxiv · Sep 2, 2020Cell Biology