Author

E. D. Spear

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Cell Biology· 3

Signature Assays, Organisms & Methods

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Approach:experimental assay· 3 Research Focus:cell signaling & trafficking· 1 Research Focus:cell type annotation· 1 Research Focus:development & morphogenesis· 1 Research Focus:differential expression· 1 Organism:mouse· 1 Organism:yeast· 1

Frequent Co-Authors

S. Michaelis· 3 shared K. O. Odinammadu· 2 shared W. Xu· 2 shared C. B. Damoci· 1 shared C.-S. Lin· 1 shared E. P. Carpenter· 1 shared H. J. Worman· 1 shared J.-Y. Shin· 1 shared

Activity by Year

2020-2021 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 28 mutual co-author links

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3 shared papersCell Biology

S. Michaelis

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3 papers

Recent·Most cited

Abolishing the prelamin A ZMPSTE24 cleavage site leads to progeroid phenotypes with near-normal longevity in mice

Y. Wang, K. Shiladardi, T. Hsu, K. O. Odinammadu, T. Maruyama, W. Wu, C.-S. Lin, C. B. Damoci, E. D. Spear, J.-Y. Shin, W. Hsu, S. Michaelis, H. J. Worman

This study shows that mice with permanently farnesylated prelamin A live nearly normal lifespans but show aging-related defects, suggesting prelamin A accumulation contributes to aging phenotypes.

bioRxiv · Nov 11, 2021Cell Biology

Defining Substrate Requirements for Cleavage of Farnesylated Prelamin A by the Integral Membrane Zinc Metalloprotease ZMPSTE24

K. M. Wood, E. D. Spear, O. W. Mossberg, K. O. Odinammadu, W. Xu, S. Michaelis

This study identifies flexible substrate requirements for ZMPSTE24 cleavage of prelamin A using a yeast system, showing that both the C-terminal and N-terminal regions have variable length and composition needs.

bioRxiv · Sep 2, 2020Cell Biology

Cleavage Site Specificity for Processing of Farnesylated Prelamin A by the Zinc Metalloprotease ZMPSTE24

T. D. Babatz, E. D. Spear, W. Xu, O. L. Sun, L. Nie, E. P. Carpenter, S. Michaelis

This study identifies sequence requirements for ZMPSTE24 cleavage of prelamin A, revealing preferences for hydrophobic residues at P1 and sensitivity of C-terminal residues.

bioRxiv · Aug 17, 2020Cell Biology