PVR and Nectin-2 blockade trigger macrophage anti-tumor functions, promote immune cell recruitment and prevent cervical tumor growth.
O.M. Diallo, Nicolas Boucherit, T. Fernez, Abdoulaye Oury Barry, E. Billion, Marie-Sarah Rouviére, Amira Ben Amara, Loane Gayraud, Jacques A. Nunès, Xavier Carcopino, Éric Lambaudie, Renaud Sabatier, Manon Richaud, Marc Lopez, Anne-Sophie Chrétien, , Laurent Gorvel
This paper shows that blocking PVR and Nectin-2 reactivates macrophage anti-tumor functions and reduces cervical tumor growth in pre-clinical models.
bioRxiv · Feb 2, 2026 · PreprintImmunology