Laurent Gorvel

The paper describes how to construct heatmaps for cell frequency and marker intensity using Excel, Phantasus, or R to improve interpretation of high-content cytometry data.

This paper shows that blocking PVR and Nectin-2 reactivates macrophage anti-tumor functions and reduces cervical tumor growth in pre-clinical models.

This study develops N4CART cells targeting Nectin-4 that overcome resistance to EV in solid tumors and show safety by avoiding skin toxicity.

This study identifies SLAMF7 and SLAMF8 as key regulators of human pDC responses to intracellular bacteria, showing their role in modulating type I IFN production and mitochondrial ROS levels.