Self-activation of Wnt signaling in pre-granulosa cells is required for ovarian folliculogenesis
Okiko Habara, Catriona Y. Logan, Masami Kanai‐Azuma, Roel Nusse, Hinako M. Takase
This study shows that Wnt signaling in pre-granulosa cells is essential for follicle activation and oocyte maturation, with a two-step model involving self-activation of Wnt and subsequent support of oocyte reawakening.
Development · Apr 24, 2021Peer-reviewedDevelopmental Biology