Roeland Nusse

The paper identifies a shared regulatory region between Wnt1 and Wnt10b that is induced by tissue injury and essential for muscle regeneration.

The paper identifies that neonatal vascularization, specifically angiogenesis in the hepatic vein periphery, determines adult liver size in mice by adding lobules.

This study uses single-cell RNA-sequencing to analyze cell type-specific responses to young or aged blood in heterochronic parabiosis, identifying mitochondrial function as a key factor in rejuvenation.

This study shows that Wnt signaling in pre-granulosa cells is essential for follicle activation and oocyte maturation, with a two-step model involving self-activation of Wnt and subsequent support of oocyte reawakening.

The paper shows that pituitary stem cells secrete WNT signals that promote the proliferation of neighboring progenitor cells.

This study shows that Wnt/β-catenin signaling, driven by endothelial cells, is critical for liver repair after acute carbon tetrachloride injury.