Hinako M. Takase

This study uses single-cell RNA sequencing to analyze WNT signaling's role in granulosa cell-oocyte interactions during primordial follicle activation, revealing transcriptomic changes and their impact on fertility.

This study shows that Wnt signaling in pre-granulosa cells is essential for follicle activation and oocyte maturation, with a two-step model involving self-activation of Wnt and subsequent support of oocyte reawakening.