Temporal mixture modelling of single-cell RNA-seq data resolves a CD4+ T cell fate bifurcation
Tapio Lönnberg, Valentine Svensson, Kylie R James, Daniel Fernandez-Ruiz, Ismail Sebina, Ruddy Montandon, Megan S. F. Soon, Lily G Fogg, Michael J. T. Stubbington, Frederik Otzen Bagger, Max Zwiessele, Neil Lawrence, Fernando Souza-Fonseca-Guimaraes, William R. Heath, Oliver Billker, , Sarah A. Teichmann
The paper uses single-cell RNA sequencing and computational modeling to resolve CD4+ T cell fate bifurcation during Plasmodium infection, showing external influence on fate decisions by monocytes.
bioRxiv · Sep 13, 2016 · PreprintSystems Biology