Oliver Billker

This paper identifies targets of dual-active antimalarials by evolving resistance to nine compounds and validates them using CRISPR and molecular docking.

This study shows that extracellular ATP (eATP) acts as an environmental cue for bacteria, altering their transcription, metabolism, and virulence.

This study uses a CRISPR homing screen to identify essential genes for malaria transmission in mosquito stages, finding a chloroquine resistance transporter-like protein critical for oocyst development.

The paper identifies 401 sex and transmission-related gene functions in malaria parasites through genetic screens, revealing conserved fertility mechanisms across eukaryotes.

The paper uses barcoded P. falciparum gene knockouts with BarSeq to phenotype parasite life cycle traits at scale.

This paper develops a chemogenomic platform using Plasmodium berghei artificial chromosomes to identify antimalarial drug targets through barcode sequencing and validation in Plasmodium falciparum.

The paper identifies ten genes critical for male and female sexual development in Plasmodium berghei and reveals a regulatory cascade governing gametogenesis.

The paper creates a comprehensive single-cell transcriptome atlas of the Plasmodium berghei life cycle and applies it to define stages in human malaria parasites.

The paper reports the genome sequencing of two avian malaria parasites and identifies lineage-specific features associated with their evolution in birds and mammals.

This study applies single-cell RNA-sequencing to malaria parasites, revealing transcriptional variation and novel gene expression patterns in sexual stages.