Genome-wide screen of cell-cycle regulators in normal and tumor cells identifies a differential response to nucleosome depletion
Maria Sokolova, Mikko Turunen, Oliver Mortusewicz, Teemu Kivioja, Patrick Herr, Anna Vaharautio, Mikael Bjorklund, Minna Taipale, Thomas Helleday, Jussi Taipale
The paper identifies CASP8AP2 as a cell-cycle regulator with differential effects on DNA replication in normal and tumor cells, leading to distinct outcomes in S-phase progression and cell survival.
Cell Cycle · Jan 5, 2017Peer-reviewedCell Biology