Minna Taipale

This paper introduces a method to simultaneously sequence genetic and epigenetic bases in DNA with single-base resolution, demonstrating accuracy and versatility in human genomic and cell-free DNA samples.

The paper investigates how transcription factors interact with nucleosomal DNA, finding that most have less access to it than free DNA and that nucleosome structure affects motif positioning and orientation.

The paper introduces ATI, a method to measure TF DNA-binding activity, and finds that few TFs with strong binding activity determine open chromatin.

The paper identifies CASP8AP2 as a cell-cycle regulator with differential effects on DNA replication in normal and tumor cells, leading to distinct outcomes in S-phase progression and cell survival.