SVEP1 enables efficient binding of Angiopoietin-2 to the TIE1 receptor, allowing receptor phosphorylation and downstream signaling
Katharina Uphoff, Melina Hußmann, Oliver Peters, Matthias Mörgelin, Fabian Metzen, Wolfgang M.J. Obermann, J. Fernando Bazán, Jörg Stetefeld, Manuel Koch, Stefan Schulte‐Merker, Dörte Schulte-Ostermann
This study identifies SVEP1 as a mediator of ANG2-TIE1 binding, leading to TIE1 phosphorylation and downstream signaling in lymphatic endothelial cells.
eLife · Oct 30, 2026Peer-reviewedDevelopmental Biology