Sodium/Potassium ATPase Alpha 1 Subunit Fine-tunes Platelet GPCR Signaling Function and is Essential for Thrombosis
Oliver Q Li, Yue Hong, Autumn R. DeHart, Renat Roytenberg, Rodrigo Aguilar, Olalekan Olanipekun, Fang Bai, Jiang Liu, Olga V. Fedorova, David J. Kennedy, Ellen A. Thompson, Sandrine V. Pierre, Wei Li
This study shows that NKA 1 enhances platelet GPCR signaling and thrombosis by binding to LGL-containing receptors, and its inhibition reduces thrombosis and sensitizes clopidogrel.
bioRxiv · May 13, 2024 · PreprintCell Biology