Autumn R. DeHart

This study identifies thymidine phosphorylase (TYMP) as a mediator of SARS-CoV-2 spike protein-induced thrombosis in mice, showing that TYMP inhibition reduces thrombosis and coagulation.

This study shows that NKA 1 enhances platelet GPCR signaling and thrombosis by binding to LGL-containing receptors, and its inhibition reduces thrombosis and sensitizes clopidogrel.

This study shows that TYMP promotes abdominal aortic aneurysm (AAA) in mice fed a Western diet by enhancing inflammation, thrombosis, and MMP2 activation while inhibiting vascular smooth muscle cell function.