A dynamic redox switch turns TRC40 into a chaperone protecting human cells against ATP-depleting, oxidative stress
Bianca Dempsey, Risai Dubrall, Olivia Chan, Kim Jasmin Lapacz, Jan Riemer, Ursula Jakob, Kathrin Ulrich
This study shows TRC40 switches from an ATP-dependent targeting factor to an ATP-independent chaperone under oxidative stress, preventing protein aggregation and supporting proteostasis.
bioRxiv · Jul 10, 2024 · PreprintCell Biology